[Indications for and results of radiotherapy of plasmacytomas].

Abstract

In therapy of plasmocytoma the radiotherapy has a well established place in addition to chemotherapy. At the Clinic and Policlinic for Radiology of the Medical Academy Erfurt 42 patients with a plasmocytoma were treated in the years 1967 to 1987, 38 of them were included into the presented study. In radiotherapy roentgen depth-therapy was used with total surface dose of 30 to 40 Gy as well as telecobalt therapy with TD of 40 to 50 Gy. 8 patients had a solitary plasmocytoma, in three times with extramedullary manifestation in mucosa of cheek and nose and in gingiva and five times with bone localisation. In 30 patients with a multiple plasmocytoma we irradiated 37 painful bone lesions; for 29 of these irradiated findings the patients stated painlessness or distinct mitigation. In two bone manifestations a pathological fracture existed additionally, in which a complete painlessness and a clear callus formation could be attained. 4 patients with an incomplete cross-section syndrome in consequence of vertebral destruction with extradural tumor spreading responded with clear mitigation and regression of paresis. Furthermore an infiltration into soft parts was diagnosed at 9 bone foci, that were reduced in part (6 infiltrations) or regressed completely (3 findings) after radiotherapy. Additionally to osseous manifestations an extramedullary tumor (peribronchial lymph-nodes, hypophysis) existed in 2 patients, that regressed completely after termination of radiotherapy. The following indications can be mentioned for radiotherapy in plasmocytoma: 1. Curative postoperative radiotherapy after exstirpation of a solitary extramedullary plasmocytoma, 2. Curative sole radiotherapy of a solitary extramedullary of medullary plasmocytoma after its histological proving.(ABSTRACT TRUNCATED AT 250 WORDS)