MORPHOLOGICAL CHANGES IN LIVER RATS TISSUES UNDER THE EXPOSURE OF ECOTOXICANTS AND PERINATAL PROPHYLAXIS

Abstract

The aim of the study was to study the morphological changes in the liver tissues of laboratory rats under the influence of ecotoxicants and during perinatal prophylaxis. The experiment was carried out on white outbred rats weighing 180-250. A total of 50 animals were involved in the experiment. All animals were divided into 5 groups: control and 4 experimental. All animals of the experimental groups were subjected to inhalation effects of gasoline and formaldehyde vapors, in the 1st (control) group, only poisoning with ecotoxicants was used, in the 2nd group, against the background of poisoning with ecotoxicants, peptinsorbent was used, in the 3rd group - a membrane protector - magnolia vine, in the 4th group beets, in the 5th experimental group - peptinsorbent, membrane protector and beets. The structure of the liver of rat pups born from female rats subjected to subchronic poisoning with gasoline and formaldehyde throughout pregnancy has pronounced pathomorphological signs characteristic of hepatosis, turning into toxic hepatitis. The use of lemongrass, peptinsorbent and beetroot separately, along with intoxication of pregnant rats, somewhat reduced the degree of pathomorphological changes in the liver of born rats, but not drastically. Against the background of using a combined mixture (peptinsorbent + lemongrass "membrane protector" + beetroot) in subsequently born rat pups, the structure of the liver is relatively better than in the control group, with the exception of certain areas of the liver, in which hemostasis and moderately pronounced dystrophic changes in hepatocytes are detected. Based on the results of the experimental study, it can be concluded that the combined mixture (peptinsorbent + lemongrass "membranoprotector" + beetroot) is effective as a hepatoprotective agent for liver damage by ecotoxicants.