Application of tumor microparticles in tumor prevention and treatment

IF 4.5 2区 工程技术 Q2 NANOSCIENCE & NANOTECHNOLOGY
Weiwei Sun, Pingwei Xu, Pengtao Pan, Sheng Guo, Rui Liu, Guojie Ji, Huanhuan Hu, Weidong Li, Lili Dai
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引用次数: 0

Abstract

Abstract Tumor microparticles (T-MPs) are vesicles released from tumor cells when they receive apoptotic or stimuli signals. T-MPs, which contain some proteins, lipids and nucleic acids from tumor cells, contribute to the exchange of material, energy and information between cells. T-MPs contain both tumor antigens and innate immunostimulatory signals, making T-MPs as a new form of tumor vaccine. Meanwhile, T-MPs can be used as natural carriers to transport ‘‘cargoes’’, such as chemotherapy drugs, oncolytic viruses, nucleic acids, and metal nanoparticles to treat tumors. In addition, T-MPs enhance the effect of chemotherapy. This review introduces the application of T-MPs as vaccines, delivery systems and chemosensitizers in tumor prevention and treatment, with a focus on the mechanisms, clinical applications, and influencing factors of drug-loaded T-MPs in tumor treatment.
肿瘤微粒在肿瘤防治中的应用
肿瘤微粒(T-MPs)是肿瘤细胞在接受凋亡或刺激信号时释放的囊泡。T-MPs含有来自肿瘤细胞的一些蛋白质、脂质和核酸,有助于细胞间物质、能量和信息的交换。T-MPs同时含有肿瘤抗原和先天免疫刺激信号,使T-MPs成为一种新型的肿瘤疫苗。同时,T-MPs可以作为天然载体运输“货物”,如化疗药物、溶瘤病毒、核酸、金属纳米颗粒等来治疗肿瘤。此外,T-MPs还能增强化疗效果。本文综述了T-MPs作为疫苗、传递系统和化学增敏剂在肿瘤预防和治疗中的应用,重点介绍了载药T-MPs在肿瘤治疗中的作用机制、临床应用和影响因素。
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来源期刊
Cancer Nanotechnology
Cancer Nanotechnology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science
CiteScore
5.20
自引率
1.80%
发文量
37
审稿时长
15 weeks
期刊介绍: Aim: Recognizing cancer as a group of diseases caused by nanostructural problems (i.e. with DNA) and also that there are unique benefits to approaches inherently involving nanoscale structures and processes to treat the disease, the journal Cancer Nanotechnology aims to disseminate cutting edge research; to promote emerging trends in the use of nanostructures and the induction of nanoscale processes for the prevention, diagnosis, treatment of cancer; and to cover related ancillary areas. Scope: Articles describing original research in the use of nanostructures and the induction of nanoscale processes for the prevention, diagnosis and treatment of cancer (open submission process). Review, editorial and tutorial articles picking up on subthemes of emerging importance where nanostructures and the induction of nanoscale processes are used for the prevention, diagnosis and treatment of cancer.
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