Serum metabolomics study of anti‐aging mechanisms of different processed Schisandra chinensis fructus products

IF 1.3 Q4 CHEMISTRY, ANALYTICAL

SEPARATION SCIENCE PLUS Pub Date : 2023-11-09 DOI:10.1002/sscp.202300133

Jinyang Dai, Bo Pang, Hui Gao

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引用次数: 0

Abstract

Abstract This study aimed to investigate the anti‐aging mechanism of raw and various processed Schisandrae chinensis fructus (SF) products by examining differences in serum metabolites in D‐galactose (D‐gal)‐induced aging rats. The study provides a metabolomic basis for SF as a tonic. The ultra‐high‐performance liquid chromatography‐Q‐time of flight‐tandem mass spectrometry technique was employed for serum metabolomic analysis of the anti‐aging effects of differently processed SF products. Multivariate statistical analysis, MetaboAnalyst, and Human Metabolome Database were utilized for pattern recognition and identification of characteristic metabolites. Enzyme‐linked immunosorbent assay results revealed significant differences between the aging model group and the blank group ( p < 0.01). Treatment with various processed SF products significantly improved related indicators in aging rats ( p < 0.05, p < 0.01). Arginine and seven other metabolites exhibited direct effects on aging. Wine‐processed Schisandrae (WS) treatment adjusted these biomarkers in aging rats to normal levels. WS significantly delayed D‐gal‐induced aging in rats by modulating endogenous biomarkers in relevant metabolic pathways, providing a scientific basis for its enhanced suitability as a tonic from a metabolomic perspective.

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五味子不同加工产品抗衰老机制的血清代谢组学研究

摘要本研究旨在通过观察D -半乳糖(D - gal)诱导衰老大鼠血清代谢物的差异，探讨生五味子和不同加工五味子产品的抗衰老机制。该研究为SF作为补品提供了代谢组学基础。采用超高效液相色谱- Q -飞行时间-串联质谱技术对不同工艺的顺丰产品进行血清代谢组学分析。利用多元统计分析、MetaboAnalyst和Human Metabolome Database进行模式识别和特征代谢物鉴定。酶联免疫吸附试验结果显示，衰老模型组与空白组之间存在显著差异(p <0.01)。各种加工后的顺丰产品处理可显著改善衰老大鼠的相关指标(p <0.05, p <0.01)。精氨酸和其他七种代谢物对衰老有直接影响。葡萄酒加工五味子(WS)治疗将衰老大鼠的这些生物标志物调节到正常水平。WS通过调节相关代谢途径中的内源性生物标志物，显著延缓D - gal诱导的大鼠衰老，从代谢组学角度为其作为补品的适用性增强提供了科学依据。

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来源期刊

SEPARATION SCIENCE PLUS CHEMISTRY, ANALYTICAL-

CiteScore

1.90

自引率

9.10%

发文量

111