Immunogenic chemotherapy sensitizes RAS-mutated colorectal cancers to immune checkpoint inhibitors

IF 6.5 2区医学 Q1 IMMUNOLOGY

Oncoimmunology Pub Date : 2023-11-09 DOI:10.1080/2162402x.2023.2272352

Lucillia Bezu, Oliver Kepp, Guido Kroemer

引用次数: 0

Abstract

Recent clinical trials have compared the use of different chemotherapeutic regimens as “immune induction therapies” to sensitize cancers to immune checkpoint inhibitors (ICI). Cytotoxic drugs reputed to be inducers of immunogenic cell death (ICD) appeared to be particularly efficient for this purpose. A trial published in Nature Medicine by Thibaudin et al. reveals the capacity of oxaliplatin-based chemotherapy to sensitize RAS-mutant unresectable metastatic colorectal cancer to ICIs blocking CTLA-4 and PD-L1.

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免疫原性化疗使ras突变的结直肠癌对免疫检查点抑制剂敏感

最近的临床试验比较了不同化疗方案作为“免疫诱导疗法”的使用，以使癌症对免疫检查点抑制剂(ICI)敏感。细胞毒性药物被认为是免疫原性细胞死亡(ICD)的诱导剂，在这方面似乎特别有效。Thibaudin等人在《自然医学》上发表的一项试验揭示了奥沙利铂为基础的化疗能够使ras突变的不可切除的转移性结直肠癌对阻断CTLA-4和PD-L1的ICIs敏感。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncoimmunology ONCOLOGYIMMUNOLOGY-IMMUNOLOGY

CiteScore

12.50

自引率

2.80%

发文量

276

审稿时长

24 weeks

期刊介绍： OncoImmunology is a dynamic, high-profile, open access journal that comprehensively covers tumor immunology and immunotherapy. As cancer immunotherapy advances, OncoImmunology is committed to publishing top-tier research encompassing all facets of basic and applied tumor immunology. The journal covers a wide range of topics, including: -Basic and translational studies in immunology of both solid and hematological malignancies -Inflammation, innate and acquired immune responses against cancer -Mechanisms of cancer immunoediting and immune evasion -Modern immunotherapies, including immunomodulators, immune checkpoint inhibitors, T-cell, NK-cell, and macrophage engagers, and CAR T cells -Immunological effects of conventional anticancer therapies.