Potential role of biosynthesized silver nanoparticles from Aaronsohnia factorovskyi on Hymenolepis nana in BALB/c mice

IF 0.4 4区农林科学 Q4 VETERINARY SCIENCES

Arquivo Brasileiro De Medicina Veterinaria E Zootecnia Pub Date : 2023-10-01 DOI:10.1590/1678-4162-13041

E. Al-Olayan, J. Almushawah, H. Alrsheed, T.M. Dawoud, R. Abdel-Gaber

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引用次数: 0

Abstract

ABSTRACT Hymenolepiasis is the most common intestinal tapeworm infection in humans caused by an intestinal cestode, Hymenolepis nana. Praziquantel (PZQ) is the most effective drug among other compounds, however, many cases of drug resistance have been reported. Recent research projects have been focused on finding novel therapeutic agents from medicinal plants. In the present study, Aaronsohnia factorovskyi was used against hymenolepiasis in the forms of plant extract (AF) and biosynthesized nanoparticles (AF-NPs) in comparison to PZQ. The results showed that 100 mg/kg AF and 0.5 mg/kg AF-NPs were the most effective doses at suppressing the fecal egg output by 98.39% and 100%, respectively. After the 10th day of treatment, it was not feasible to detect the presence of H. nana eggs in the fecal sample’s examination in the AF-NPs group. Upon treatment with AF-NPs, there were more improvements in the structure of the intestinal tissue than the effect of AF alone and in comparison, to PZQ. Collectively, results showed that A. factoryviski can be used as an anti-hymenolepiasis treatment with minimum side effects and less cost. Also, it was found that NPs are the most effective way, as it offers a faster recovery rate in comparison to natural plant extract.

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生物合成银纳米粒子对BALB/c小鼠膜膜绦虫的潜在作用

膜膜绦虫病是人类最常见的肠道绦虫感染，由一种肠道绦虫引起。吡喹酮(PZQ)是其他化合物中最有效的药物，但也有许多耐药病例的报道。最近的研究项目集中在从药用植物中寻找新的治疗药物。在本研究中，与PZQ相比，以植物提取物(AF)和生物合成纳米颗粒(AF- nps)的形式使用factorovskyi Aaronsohnia防治膜膜癣。结果表明，100 mg/kg AF和0.5 mg/kg AF- nps对粪蛋产量的抑制效果最佳，分别为98.39%和100%。治疗第10天后，AF-NPs组粪便样品检查中已无法检测到H. nana卵。经AF- nps治疗后，肠道组织结构的改善比AF单独治疗和与PZQ相比有更多的改善。综上所述，臭臭草可作为一种副作用小、费用低的抗膜膜癣药物。此外，发现NPs是最有效的方法，因为与天然植物提取物相比，它提供了更快的恢复速度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arquivo Brasileiro De Medicina Veterinaria E Zootecnia 农林科学-兽医学

CiteScore

0.80

自引率

25.00%

发文量

111

审稿时长

9-18 weeks

期刊介绍： Publica artigos originais de pesquisa sobre temas de medicina veterinária, zootecnia, tecnologia e inspeção de produtos de origem animal e áreas afins relacionadas com a produção animal. Atualmente a revista mantém 628 permutas (419 internacionais e 209 nacionais), sendo um verdadeiro suporte para o recebimento de periódicos pela Biblioteca da Escola. A partir de 1999, a Escola de Veterinária delegou à FEP MVZ Editora o encargo do gerenciamento e edição de todas suas publicações, inclusive do Arquivo, ficando somente com o apoio logístico (instalações, equipamentos, pessoal etc.). O apoio financeiro é exercido pelo CNPq/FINEP e pela própria FEP MVZ.