Improved Antiproliferative Activity of Doxorubicin-Loaded Calcium Phosphate Nanoparticles Against Melanoma Cells

IF 1 4区生物学 Q3 BIOLOGY

Brazilian Archives of Biology and Technology Pub Date : 2023-01-01 DOI:10.1590/1678-4324-2023220572

Igor Barbosa Lima, Betania Mara Alvarenga, Priscila Izabel Santos de Tótaro, Fernanda Boratto, Elaine Amaral Leite, Pedro Pires Goulart Guimaraes

引用次数: 1

Abstract

HIGHLIGHTS N-Dox has higher activity against A-375 cells than free doxorubicin. The formulation has higher selectivity indices than free doxorubicin. Treatment induced senescence and no colonies recovered after short-term exposure.

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负载阿霉素的磷酸钙纳米颗粒对黑色素瘤细胞的抗增殖活性提高

N-Dox对A-375细胞的活性高于游离阿霉素。该制剂具有比游离阿霉素更高的选择性指标。处理引起衰老，短期暴露后没有菌落恢复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brazilian Archives of Biology and Technology 生物-生物学

CiteScore

1.80

自引率

0.00%

发文量

116

审稿时长

3 months

期刊介绍： Information not localized