Xueqin Wang, Xi Ye, Xiaoping Qin, Yi Fu, Hong Tang
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引用次数: 0
Abstract
Tumor microenvironment responsive probe holds great potential to achieve precise diagnosis owning to its capacity to show different signal in tumor and normal tissue. Here, we develop an intelligent magnetic resonance imaging (MRI) contrast agent (CA) with the capacity to rapidly respond to GSH. This intelligent MRI CA keep in “off” state in normal tissue while degrade into manganese ions and exhibit “on” state in tumor lesion. This unique feature endows this activable MRI CA to fulfill accurate tumor detection. Besides, this intelligent CA show negligible cytotoxicity to cell and mice, indicating its excellent biocompatibility and immense potential to biological application. This work develops a new activable MRI CA to sensitively detect tumor and provides guidelines to design new activable MRI CA for precise diagnosis.
肿瘤微环境响应探针能在肿瘤和正常组织中显示不同的信号，因此在实现精确诊断方面具有巨大潜力。在这里，我们开发了一种智能磁共振成像（MRI）造影剂（CA），它能对 GSH 快速反应。这种智能磁共振成像造影剂在正常组织中保持 "关闭 "状态，而在肿瘤病灶中降解为锰离子并呈现 "开启 "状态。这一独特功能使这种可激活的磁共振成像 CA 能够准确检测肿瘤。此外，这种智能 CA 对细胞和小鼠的细胞毒性几乎可以忽略不计，这表明它具有良好的生物相容性和巨大的生物应用潜力。这项研究开发了一种新型可激活磁共振成像 CA，可灵敏地检测肿瘤，并为设计新型可激活磁共振成像 CA 进行精确诊断提供了指导。
期刊介绍：
Applied Magnetic Resonance provides an international forum for the application of magnetic resonance in physics, chemistry, biology, medicine, geochemistry, ecology, engineering, and related fields.
The contents include articles with a strong emphasis on new applications, and on new experimental methods. Additional features include book reviews and Letters to the Editor.
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