New 1, 2, 3-triazole-Furan Scaffold Schiff bases: Design, Synthesis, Characterization and biological studies

Abstract

In the present investigation, Schiff bases (SBs) bearing 1, 2, 3-triazole and furan motif were synthesized through condensation reaction via conventional approach (Route-A) and solvent free approach (Route-B). It has been found that route-B is efficient since it is eco friendly with short reaction time and satisfactory yield than route-A. The structure and formation of targeted Schiff bases (SBs) were confirmed by different spectroscopic techniques (1H NMR, 13C NMR and Mass). Finally, in vitro antimicrobial screening result revealed that the synthesised SBs derivatives may act as moderate antimicrobial agents.