Investigation of Hereditary Cholesterol Deficiency (CD) in Holstein Cattle at the State Farms in Türkiye

IF 0.7 4区农林科学 Q3 VETERINARY SCIENCES

Ankara Universitesi Veteriner Fakultesi Dergisi Pub Date : 2023-08-15 DOI:10.33988/auvfd.1295330

Ceyhan ÖZBEYAZ, Melike ÖZCAN

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引用次数: 0

Abstract

Türkiye is exposed to international animal and semen movements. For this reason, Türkiye is very affected by diseases and hereditary disorders. State Farms is a state organization that raises and distributes breeding cattle. This study was aimed at investigating the presence and distribution of mutant alleles causing cholesterol deficiency (CD) disorder in Holstein cattle on state farms. For this purpose, blood and sperm samples were collected from 466 Holstein cattle. The real-time PCR method was used for genotyping. A total of seven cattle were found to be heterozygous. The frequency of the mutant allele was determined to be 0.75%. The kinship of four cattle carrying the mutant allele with Mauglin Storm, the bull in which this disease was first detected, was determined. The presence of cattle carrying the mutant allele in Türkiye is quite low compared to other countries. The Apolipoprotein-B (APOB) mutant allele was found at low frequencies and detected for the first time in Türkiye with this research. Therefore, it is necessary to develop control programs by screening other Holstein herds.

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基耶州国营农场荷斯坦牛遗传性胆固醇缺乏(CD)的调查

基耶病毒受国际动物和精液流动的影响。因此， rkiye很容易受到疾病和遗传性疾病的影响。国营农场是饲养和分配种牛的国家组织。本研究旨在调查国营农场荷斯坦牛中引起胆固醇缺乏症(CD)的突变等位基因的存在和分布。为此，从466头荷斯坦牛身上采集了血液和精子样本。采用实时荧光定量PCR法进行基因分型。共发现7头牛为杂合子。突变等位基因的频率测定为0.75%。确定了携带突变等位基因的4头牛与首次发现该病的Mauglin Storm的亲缘关系。与其他国家相比，携带突变等位基因的牛在 rkiye中的存在率相当低。载脂蛋白b (APOB)突变等位基因在猕猴中发现频率较低且首次检测到。因此，有必要通过筛选其他荷斯坦猪群来制定防治方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ankara Universitesi Veteriner Fakultesi Dergisi 农林科学-兽医学

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Ankara Üniversitesi Veteriner Fakültesi Dergisi is one of the journals’ of Ankara University, which is the first well-established university in the Republic of Turkey. Research articles, short communications, case reports, letter to editor and invited review articles are published on all aspects of veterinary medicine and animal science. The journal is published on a quarterly since 1954 and indexing in Science Citation Index-Expanded (SCI-Exp) since April 2007.