Analysis of the risk of future gastrointestinal surgery in Crohn’s disease with stricture

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-10-25 DOI:10.4103/sjg.sjg_256_23

Wen Zeng, Yong Chen, Bolong Yin, Xue Wen, Jian Xiao, Lian Luo, Haiyuan Tang, He Zheng

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引用次数: 0

Abstract

Abstract Background: Stricture in patients with Crohn’s disease (CD) carries a high risk of CD-related surgery in the course of the disease. The aim of this study was to assess the rate of occurrence of CD-related surgery and to determine baseline risk factors predicting subsequent surgery in this patient group. Methods: Patients registered with stricturing CD were included. All baseline and follow-up data were collected retrospectively. Patients attended the clinic for follow-up at week 14 to assess their response to infliximab (IFX). CD-related surgery was the observational endpoint. Univariate and multivariate Cox regression analyses were used. Results: A total of 123 patients with stricturing CD were included in this study. The cumulative risk of CD-related surgery for years 1–5 after diagnosis was 18.0%, 26.7%, 32.6%, 40.7%, and 46.4%, respectively. Prior gastrointestinal (GI) surgery, low body mass index (BMI), and high platelet count might be risk factors for future CD-related surgery. With 97 participants treated by IFX, prior GI surgery and primary non-response (PNR) to IFX correlated with future CD-related surgery. Conclusion: Prior GI surgery, BMI, and platelet counts were related to future CD-related surgery. Patients who were PNR to IFX had a higher risk of CD-related surgery in the future.

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克罗恩病合并狭窄患者未来胃肠手术的风险分析

背景:克罗恩病(CD)患者的狭窄在病程中具有较高的CD相关手术风险。本研究的目的是评估该患者组cd相关手术的发生率，并确定预测后续手术的基线危险因素。方法:纳入登记的狭窄性CD患者。所有基线和随访数据回顾性收集。患者在第14周到诊所进行随访，以评估他们对英夫利昔单抗(IFX)的反应。cd相关手术是观察终点。采用单因素和多因素Cox回归分析。结果:本研究共纳入123例狭窄性CD患者。诊断后1-5年cd相关手术的累积风险分别为18.0%、26.7%、32.6%、40.7%和46.4%。既往胃肠道(GI)手术，低体重指数(BMI)和高血小板计数可能是未来cd相关手术的危险因素。在97名接受IFX治疗的参与者中，先前的胃肠道手术和对IFX的原发性无反应(PNR)与未来的cd相关手术相关。结论:既往GI手术、BMI和血小板计数与未来cd相关手术相关。PNR至IFX的患者在未来发生cd相关手术的风险更高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.