The Potential Role of Soybean Bioactive Peptides in the Prevention and Cure of Carcinoma and Cardiovascular Disorder

Q2 Pharmacology, Toxicology and Pharmaceutics

Current Bioactive Compounds Pub Date : 2023-09-07 DOI:10.2174/1573407219666230907115809

Kuldeep Singh, Jeetendra Kumar Gupta, Shivendra Kumar, Talever Singh

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引用次数: 0

Abstract

Abstract: Bioactive peptides derived from soybeans have recently been identified as having potential health benefits for preventing and curing cancer and cardiovascular disorders. This narrative review focuses on the potential role of these peptides in such conditions and the possible mechanisms by which they may act. Soybean-derived bioactive peptides have been found to possess antitumor, antioxidant, anti-inflammatory, and cholesterol-lowering effects. Animal and in vitro studies have demonstrated that these peptides can modulate multiple signaling pathways, including those involved in the regulation of apoptosis, angiogenesis, and cell proliferation. Furthermore, they may protect against oxidative stress and lipid accumulation, which are associated with cancer and cardiovascular diseases. Also, soybean peptides have been shown to stop enzymes from breaking down cancer-causing chemicals and reduce the production of pro-inflammatory cytokines, which are linked to a higher risk of heart disease. The potential of soybean-derived peptides as a therapeutic tool in cancer and cardiovascular diseases is promising. However, further studies are needed to elucidate their mechanisms of action and assess their safety and efficacy in clinical settings.

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大豆生物活性肽在防治癌症和心血管疾病中的潜在作用

摘要:近年来，从大豆中提取的生物活性肽被发现在预防和治疗癌症和心血管疾病方面具有潜在的健康益处。这篇叙述性综述的重点是这些肽在这种情况下的潜在作用以及它们可能起作用的可能机制。大豆衍生的生物活性肽已被发现具有抗肿瘤、抗氧化、抗炎和降低胆固醇的作用。动物和体外研究表明，这些肽可以调节多种信号通路，包括参与调节细胞凋亡、血管生成和细胞增殖的信号通路。此外，它们还可以防止与癌症和心血管疾病相关的氧化应激和脂质积累。此外，大豆肽已被证明可以阻止酶分解致癌化学物质，减少促炎细胞因子的产生，而促炎细胞因子与心脏病的高风险有关。大豆衍生肽作为癌症和心血管疾病治疗工具的潜力是有希望的。然而，需要进一步的研究来阐明其作用机制，并评估其在临床环境中的安全性和有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Bioactive Compounds Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.90

自引率

0.00%

发文量

112

期刊介绍： The journal aims to provide comprehensive review articles on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia. The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.