Cytotoxic Activities on Human Ovarian Cancer Cell Lines by Neolignans and Diarylnonanoids from the Seed of Myristica fragrans Houtt

Q3 Chemistry

Natural product sciences Pub Date : 2023-09-30 DOI:10.20307/nps.2023.29.3.171

Viet Phong Nguyen, Ha-Yeong Chae, Vu Thi Oanh, Byung-Sun Min, Mi-Jeong Kwon, Jeong-Ah Kim

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引用次数: 0

Abstract

Ovarian cancer is a primary global health concern, often diagnosed at advanced stages with limited treatment options and poor prognosis. Natural products have emerged as potential sources of safe and effective therapies. From the seeds of Myristica fragrans Houtt. (nutmeg), 24 compounds, including neolignans and diarylnonanoid derivatives, were isolated and structurally elucidated. The cytotoxic activities of these isolated metabolites against cisplatin-sensitive and resistant human ovarian cancer cell lines were evaluated. In particular, myrifragranone C (23) exhibited cytotoxicity against all test cancer cell lines A2780, TOV-112D, and SK-OV3 with ICSUB50/SUB values of 14.1, 16.9, and 33.4 M, respectively. Furthermore, compound 23 induced the death of A2780 and SK-OV3 cancer cells via apoptosis. Western blotting revealed that compound 23 significantly increased the expression of cleaved caspase-3 and poly-ADP ribose polymerase and promoted apoptosis via the mitogenactivated protein kinase signaling pathway. Our findings may provide a preliminary understanding of the antiovarian cancer effect of the active compound myrifragranone C as a potential treatment using natural products.

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香肉豆蔻种子中新木脂素和芳二酰壬烷类化合物对人卵巢癌细胞株的细胞毒活性

卵巢癌是一个主要的全球健康问题，通常在晚期诊断，治疗选择有限，预后差。天然产物已成为安全有效疗法的潜在来源。来自胡特肉豆蔻的种子。从肉豆蔻中分离得到24个化合物，包括新木脂素和二芳基壬烷衍生物，并进行了结构鉴定。这些分离的代谢物对顺铂敏感和耐药的人卵巢癌细胞系的细胞毒活性进行了评估。特别是，肉豆蔻蓝酮C(23)对所有试验癌细胞系A2780、TOV-112D和SK-OV3均表现出细胞毒性，ICSUB50/SUB值分别为14.1、16.9和33.4M。此外，化合物23通过凋亡诱导A2780和SK-OV3癌细胞死亡。Western blotting结果显示，化合物23可显著增加cleaved caspase-3和poly-ADP核糖聚合酶的表达，并通过有丝分裂原激活蛋白激酶信号通路促进细胞凋亡。我们的研究结果可能提供了一个初步的了解，活性化合物豆蔻蓝酮C抗卵巢癌的作用，作为一个潜在的治疗使用天然产物。

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来源期刊

Natural product sciences Chemistry-Organic Chemistry

CiteScore

1.80

自引率

0.00%

发文量

期刊介绍： Natural Product Sciences is the official publication of the Korean Society of Pharmacognosy which was launched in 1995. The journal is published quarterly at the end of March, June, September, and December each year and the official title of the journal is abbreviated title as "Nat. Prod. Sci." The research papers on original work, either experimental or theoretical, that advance our understanding of natural product sciences, including important questions of phytochemistry, chemistry, and bio-chemistry of natural resources will be published. Timely reviews and commentaries on recent progress in active areas of natural products research will be also published.