Effect Of Aegle marmelos on IgM And IgG Antibody Titers in Rattus norvegicus

Jurnal Ilmu dan Teknologi Kesehatan (e-journal) Pub Date : 2023-09-30 DOI:10.32668/jitek.v11i1.1314

Kadeq Novita Prajawanti, Arif Rahman Nurdianto, Novia Rahmawati, Yohanes Ardian Kapri Negara

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Abstract

Aegle marmelos is a traditional plant with many therapeutic benefits; for example, it is used as an immunomodulatory agent. Literature studies reveal many functional and bioactive compounds, such as alkaloids, phenolics, coumarins, flavonoids, terpenoids, and other antioxidants. Based on its chemical content, Aegle marmelos could be an immunomodulatory agent because it can stimulate the production of antibodies against foreign antigens, increasing IgM and IgG. This study aims to determine the effect of Aegle marmelos filtrate on IgM and IgG titers in Rattus norvergicus induced (sheep red blood cells) SRBC 2%. In this study, 30 rats were divided into five groups: negative control received standard diets, positive control received SRBC 2% injection, P1 received SRBC 2% + Aegle marmelos filtrate 25%, P2 received SRBC 2% + Aegle marmelos filtrate 50%, and P3 received SRBC 2% + Aegle marmelos filtrate 75%. The results showed that administration of Aegle marmelos filtrate could increase IgM titers at the highest dose of 75%, although it was not statistically significant. Meanwhile, Aegle marmelos filtrate does not affect IgG titers in SRBC 2% compared to treatment groups.

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蜜桔对褐家鼠IgM和IgG抗体滴度的影响

柑橘是一种传统植物，具有许多治疗益处;例如，它被用作免疫调节剂。文献研究揭示了许多功能性和生物活性化合物，如生物碱、酚类、香豆素、类黄酮、萜类和其他抗氧化剂。根据其化学成分，艾格尔甜瓜可能是一种免疫调节剂，因为它可以刺激产生针对外来抗原的抗体，增加IgM和IgG。本实验旨在测定蜜瓜凝胶滤液对褐家鼠诱导的(羊红细胞)SRBC 2%中IgM和IgG滴度的影响。本研究将30只大鼠分为5组:阴性对照组给予标准饲料，阳性对照组给予SRBC 2%注射，P1给予SRBC 2% +埃格尔甜瓜滤液25%，P2给予SRBC 2% +埃格尔甜瓜滤液50%，P3给予SRBC 2% +埃格尔甜瓜滤液75%。结果显示，艾格滤液可使IgM滴度升高，最高剂量为75%，但无统计学意义。同时，与治疗组相比，艾格尔甜瓜滤液不影响2% SRBC中IgG滴度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Jurnal Ilmu dan Teknologi Kesehatan (e-journal)

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