Effect of Penicillin on Hematological and Plasma Biochemical Parameters in Female Wistar Rats

Q3 Pharmacology, Toxicology and Pharmaceutics

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI:10.13005/bpj/2719

Oyedeji K. O, Momoh R.O.

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Abstract

An antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of such infections. This study was designed to investigate effect of penicillin on blood parameters in female rats. Ten female Wistar rats (130 – 150 g) were grouped into control and penicillin (17.14 mg/kg) – treated groups for blood assay. The penicillin was administered orally for 50 days. Haematological assay was carried out using haemocytometer, while biochemical assay was carried out using spectrophotometry. Mean +/- SEM and student’s t-test at p<0.05 were determined. Penicillin (17.14 mg/kg) significantly decreased haemoglobin and lymphocyte values, but induced significant increase in eosinophil value relative to their controls. It also significantly decreased total protein and ALP values relative to their controls. Conclusively, it can be suggested that penicillin had harmful effects on blood parameters in female Wistar rats via induction of significant reductions in hemoglobin, lymphocyte and total protein values. However, it also had advantageous effects on blood parameters in female Wistar rats via induction of significant increase in eosinophil value as well as significant decrease in ALP activity.

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青霉素对雌性Wistar大鼠血液学及血浆生化指标的影响

抗生素是一种对细菌有效的抗菌物质。它是对抗细菌感染的最重要类型的抗菌剂，抗生素药物被广泛用于治疗和预防这种感染。本研究旨在探讨青霉素对雌性大鼠血液指标的影响。将雌性Wistar大鼠10只(130 ~ 150 g)分为对照组和青霉素(17.14 mg/kg)处理组进行血液测定。青霉素口服50天。血液学测定采用血细胞计，生化测定采用分光光度法。均数+/- SEM和学生t检验在p<0.05。青霉素(17.14 mg/kg)显著降低血红蛋白和淋巴细胞值，但诱导嗜酸性粒细胞值相对于对照组显著升高。与对照组相比，它也显著降低了总蛋白和ALP值。由此可见，青霉素通过诱导血红蛋白、淋巴细胞和总蛋白的显著降低，对雌性Wistar大鼠的血液参数有有害影响。然而，它对雌性Wistar大鼠的血液参数也有有利的影响，通过诱导嗜酸性粒细胞值显著增加和ALP活性显著降低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical and Pharmacology Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

1.20

自引率

0.00%

发文量

189

期刊介绍： Biomedical and Pharmacology Journal (BPJ) is an International Peer Reviewed Research Journal in English language whose frequency is quarterly. The journal seeks to promote research, exchange of scientific information, consideration of regulatory mechanisms that affect drug development and utilization, and medical education. BPJ take much care in making your article published without much delay with your kind cooperation and support. Research papers, review articles, short communications, news are welcomed provided they demonstrate new findings of relevance to the field as a whole. All articles will be peer-reviewed and will find a place in Biomedical and Pharmacology Journal based on the merit and innovativeness of the research work. BPJ hopes that Researchers, Research scholars, Academician, Industrialists etc. would make use of this journal for the development of science and technology. Topics of interest include, but are not limited to: Biochemistry Genetics Microbiology and virology Molecular, cellular and cancer biology Neurosciences Pharmacology Drug Discovery Cardiovascular Pharmacology Neuropharmacology Molecular & Cellular Mechanisms Immunology & Inflammation Pharmacy.