Evaluation of Antioxidant Activity of Secang Wood (Caesalpinia Sappan L) Water Extract in Wistar Rats

Q3 Pharmacology, Toxicology and Pharmaceutics

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI:10.13005/bpj/2734

Ida Ayu Raka Astiti Asih, I Ketut Giri Harta Subawa, I Made Oka Adi Parwata

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Abstract

Secang (Caesalpinia sappan L.) has a good effect on the health of the human body traditionally. It is a plant that has antioxidant activity because containing phenol and flavonoid compounds. The focus of this study was to evaluate the antioxidant activity of Secang wood water extract in vitro and in vivo. The Ferric Reducing Antioxidant Power method is used to examine antioxidant activity in vitro, while Wistar rats are used to test it in vivo. Test animals are given orally 50 mg/kgBW of the Secang wood water extract. Malondialdehyde levels and Superoxide Dismutase activity in rat heart and liver tissue with maximum physical activity were measured after the five-day intervention. In vitro, tests revealed that Secang wood water extract, which contained 393.7374 mg AAE/g of the sample, had the highest antioxidant capacity. In vivo, a test revealed that consumption of Secang wood water extract significantly (p < 0.05) boosted Superoxide Dismutase activity and lowered Malondialdehyde levels in the Wistar rats compared to the control.

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四苍木水提物对Wistar大鼠抗氧化活性的评价

传统意义上，塞姜(Caesalpinia sappan L.)具有良好的人体保健作用。它是一种具有抗氧化活性的植物，因为它含有酚和类黄酮化合物。本研究的重点是评价四苍木水提取物的体外和体内抗氧化活性。采用铁还原抗氧化力法测定体外抗氧化活性，Wistar大鼠体内抗氧化活性。实验动物口服50 mg/kgBW的苍木水提取物。干预5天后，测量最大体力活动大鼠心脏和肝脏组织丙二醛水平和超氧化物歧化酶活性。体外实验结果表明，参苍木水提物的抗氧化能力最高，其AAE含量为393.7374 mg /g。体内试验表明，食用松茸木水提取物可显著降低(p <0.05)提高了Wistar大鼠的超氧化物歧化酶活性，降低了丙二醛水平。

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来源期刊

Biomedical and Pharmacology Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

1.20

自引率

0.00%

发文量

189

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