Targeted Pharmaceutical Analysis of Antibiotic Use by Risk Criteria in Patients Hospitalized in the Infectious and Tropical Diseases Department at Treichville Teaching Hospital (Abidjan, Côte d'Ivoire)

Q3 Pharmacology, Toxicology and Pharmaceutics

Biomedical and Pharmacology Journal Pub Date : 2023-09-30 DOI:10.13005/bpj/2727

Joseph Eric Balayssac, Lenoir Thierry Ayoman Djadji, Brou N’Guessan Aimé, Awa Nounaferi Gnieneferetien Silue, Eric Gbongue Tia, Serge Paul Eholié

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引用次数: 0

Abstract

Introduction: Most pharmacotherapeutic problems in hospitals are caused by anti-infectives. Audit of prescriptions by a clinical pharmacist is a control and prevention element for iatrogenic risks. Objective: The main aim of our study was to assess the use of antibiotics according to risk criteria in patients hospitalized in the infectious diseases Unit of the Treichville Teaching Hospital (Abidjan, Ivory Coast). Methods: This cross-sectional descriptive study conducted from August to December 2022 in the Infectious and Tropical Diseases department of the Treichville University Hospital aimed to analyze the use of antibiotics in patients with risk criteria. The tools for detecting pharmacotherapeutic problems allowed us to evaluate the frequency and nature of pharmaceutical interventions, highlighting the role of the pharmacist in patient management. Data were analyzed using SPSS version 20.0 software (IBM, USA). Results: A total of 88 patients were included in the study, with a majority of singles (54.5%) and a predominance of subjects under 45 years of age (87.6%) and HIV-positive (93.2%). Antibiotics were the most frequent treatment (75.1%), followed by beta-lactams (36.7%). The main drug interactions were precautions for use (53.6%) and contraindicated associations (45.6%), especially the combination of Ofloxacin with bivalent cations or didanosine. The main pharmaceutical interventions proposed were monitoring of biological parameters in at-risk patients (68.8%) and drug substitution (14.8%). All proposed pharmaceutical interventions were accepted by prescribers. Risk criteria associated with the use of antibiotics were significantly associated with the nature of proposed pharmaceutical interventions. Conclusion: In conclusion, the use of antibiotics in patients with risk criteria is common in the Infectious and Tropical Diseases department of the Treichville University Hospital. The results emphasize the importance of prescription audit by a clinical pharmacist in detecting pharmacotherapeutic problems and preventing iatrogenic risks. The proposed pharmaceutical interventions were accepted by prescribers and were tailored to the risk criteria associated with the use of antibiotics.

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Treichville教学医院传染病和热带病科住院患者按风险标准使用抗生素的针对性药物分析(阿比让，Côte科特迪瓦)

医院的药物治疗问题大多是由抗感染药物引起的。临床药师对处方的审核是控制和预防医源性风险的一个要素。目的:本研究的主要目的是评估Treichville教学医院(科特迪瓦阿比让)传染病科住院患者根据风险标准使用抗生素的情况。方法:本横断面描述性研究于2022年8月至12月在Treichville大学医院感染性和热带病科进行，旨在分析具有风险标准的患者的抗生素使用情况。检测药物治疗问题的工具使我们能够评估药物干预的频率和性质，强调药剂师在患者管理中的作用。数据分析采用SPSS 20.0版软件(IBM, USA)。结果:共纳入88例患者，其中以单身为主(54.5%)，以45岁以下为主(87.6%)，hiv阳性(93.2%)。抗生素是最常见的治疗方法(75.1%)，其次是β -内酰胺类药物(36.7%)。主要的药物相互作用为使用时注意事项(53.6%)和禁忌症(45.6%)，尤其是氧氟沙星与二价阳离子或二腺苷的联用。建议的主要药物干预措施是监测高危患者的生物学参数(68.8%)和药物替代(14.8%)。所有建议的药物干预措施均被开处方者接受。与抗生素使用相关的风险标准与拟议的药物干预措施的性质显著相关。结论:结论:在Treichville大学医院感染性和热带病科，符合危险标准的患者普遍使用抗生素。结果强调了临床药师审核处方在发现药物治疗问题和预防医源性风险中的重要性。建议的药物干预措施被开处方者接受，并根据与使用抗生素相关的风险标准进行了调整。

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来源期刊

Biomedical and Pharmacology Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

1.20

自引率

0.00%

发文量

189

期刊介绍： Biomedical and Pharmacology Journal (BPJ) is an International Peer Reviewed Research Journal in English language whose frequency is quarterly. The journal seeks to promote research, exchange of scientific information, consideration of regulatory mechanisms that affect drug development and utilization, and medical education. BPJ take much care in making your article published without much delay with your kind cooperation and support. Research papers, review articles, short communications, news are welcomed provided they demonstrate new findings of relevance to the field as a whole. All articles will be peer-reviewed and will find a place in Biomedical and Pharmacology Journal based on the merit and innovativeness of the research work. BPJ hopes that Researchers, Research scholars, Academician, Industrialists etc. would make use of this journal for the development of science and technology. Topics of interest include, but are not limited to: Biochemistry Genetics Microbiology and virology Molecular, cellular and cancer biology Neurosciences Pharmacology Drug Discovery Cardiovascular Pharmacology Neuropharmacology Molecular & Cellular Mechanisms Immunology & Inflammation Pharmacy.