Uncovering the Mechanism of Fuzi and Baishao in Treating Rheumatoid Arthritis Using Systems Pharmacology and Molecular Docking

Abstract

Background and ObjectivesTraditional Chinese Medicine has been implemented in clinical practice for thousands of years to treat rheumatoid arthritis (RA). Aconitum carmichaelii Debx (Fuzi) and Paeonia lactiflora Pall (Baishao) are a common herb-pair that is used in many herbal prescriptions to treat RA. However, the mechanism of Fuzi and Baishao for treating RA remains unclear. Here, we used a systems pharmacology and molecular docking approach to investigate the mechanism of Fuzi and Baishao in the treatment of RA.