A study of E-cadherin expression in esophageal carcinoma

CP Manjula, B Meghana
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Abstract

Background and Aim: Esophageal carcinoma is one of the most aggressive malignancies of the gastrointestinal tract. E-cadherin is a transmembrane glycoprotein and its expression is associated with tumor invasiveness, metastasis, survival, and prognosis. The present study aims to compare the pattern of E-cadherin expression in esophageal carcinoma. Materials and Methods: This is a retrospective study conducted over a period of 5 years. Expression of E-cadherin was evaluated on paraffin-embedded sections of esophageal carcinoma. The immunoreactive scores (IRSs) were calculated and compared with tumor differentiation. Results: The present study included 45 esophageal biopsies, of which 40 cases were neoplastic and 5 were nonneoplastic. The most common histological type is squamous cell carcinoma (SCC), of which well-differentiated SCC (WDSCC) was 12.5%, moderately differentiated SCC 57.5%, and poorly differentiated SCC (PDSCC) 17.5%. The IRS was highest in WDSCC and least in PDSCC, with a mean score of 7.20 and 1.57, respectively. This difference was statistically significant with P = 0.001. Conclusion: E-cadherin is an important prognostic marker in esophageal SCC. Its expression is inversely correlated with tumor differentiation. WDSCC and AC exhibit strong E-cadherin expression. Reduced expression of E-cadherin is more likely to be associated with PDSCC of the esophagus.
食管癌组织中e -钙粘蛋白表达的研究
背景与目的:食管癌是最具侵袭性的胃肠道恶性肿瘤之一。e -钙粘蛋白是一种跨膜糖蛋白,其表达与肿瘤侵袭、转移、生存和预后有关。本研究旨在比较E-cadherin在食管癌中的表达模式。材料和方法:这是一项为期5年的回顾性研究。食管癌石蜡包埋切片检测E-cadherin的表达。计算免疫反应评分(IRSs)并与肿瘤分化进行比较。结果:本组食管活检45例,其中肿瘤40例,非肿瘤5例。最常见的组织学类型是鳞状细胞癌(SCC),其中高分化SCC (WDSCC)占12.5%,中分化SCC占57.5%,低分化SCC (PDSCC)占17.5%。WDSCC的IRS最高,PDSCC最低,平均评分分别为7.20和1.57。差异有统计学意义,P = 0.001。结论:e -钙粘蛋白是食管鳞状细胞癌重要的预后指标。其表达与肿瘤分化呈负相关。WDSCC和AC表现出强烈的E-cadherin表达。e -钙粘蛋白表达降低更可能与食道PDSCC相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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