Therapeutic effects of Chinese herbal medicines for treatment of urolithiasis: A review

IF 4.7 4区医学 Q1 CHEMISTRY, MEDICINAL

Chinese Herbal Medicines Pub Date : 2023-10-01 DOI:10.1016/j.chmed.2023.09.001

Chen Jiang , Lingyun Wang , Yang Wang , Rongjia Xu , Hongtao Yang , Jibin Peng

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Abstract

Urolithiasis is a common and complex disease of the urinary system, which can cause urinary tract blockage, urinary tract infection, and even damage to urinary system-related tissues. Although urolithiasis can be cured, its high recurrence rate and the development of chronic kidney disease in some patients have drawn the attention of nephrologists. Although the application of extracorporeal lithotripsy, percutaneous nephrolithotomy and other minimally invasive techniques have made the treatment of urolithiasis more efficient, pharmacotherapy plays an indispensable role in reducing their morbidity and recurrence rates. Traditional Chinese medicine (TCM) has been used for treatment and prevention of urolithiasis in developing countries for centuries, known for its unquestionable efficacy and safety. This article reviews the progress of clinical trials and pharmacological studies on the treatment of urolithiasis with Chinese herbal medicines (CHMs). The mechanism of CHMs in the treatment of urolithiasis mainly involve preventing further growth and aggregation of urolithiasis, reducing the PH of urine, promoting calculus dissolution. Furthermore, some CHMs can increase urine output, relax smooth muscles, and promote the removal of calculus. These findings provide new treatment strategies and options for urolithiasis and secondary kidney damage.

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中药治疗尿石症的疗效综述

尿石症是泌尿系统常见的复杂疾病，可引起尿路阻塞、尿路感染，甚至损害泌尿系统相关组织。虽然尿石症可以治愈，但其高复发率和部分患者发展为慢性肾脏疾病引起了肾病学家的注意。尽管体外碎石术、经皮肾镜取石术等微创技术的应用使尿石症的治疗更加有效，但药物治疗在降低其发病率和复发率方面发挥着不可或缺的作用。几个世纪以来，发展中国家一直使用中医治疗和预防尿石症，其疗效和安全性毋庸置疑。本文综述了中药治疗尿石症的临床试验和药理研究进展。中药治疗尿石症的机制主要包括防止尿石症的进一步生长和聚集，降低尿液PH值，促进结石溶解。此外，一些中药可以增加尿量，放松平滑肌，促进结石的清除。这些发现为尿石症和继发性肾损害提供了新的治疗策略和选择。

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来源期刊

Chinese Herbal Medicines CHEMISTRY, MEDICINAL-

CiteScore

4.40

自引率

5.30%

发文量

629

审稿时长

10 weeks

期刊介绍： Chinese Herbal Medicines is intended to disseminate the latest developments and research progress in traditional and herbal medical sciences to researchers, practitioners, academics and administrators worldwide in the field of traditional and herbal medicines. The journal's international coverage ensures that research and progress from all regions of the world are widely included. CHM is a core journal of Chinese science and technology. The journal entered into the ESCI database in 2017, and then was included in PMC, Scopus and other important international search systems. In 2019, CHM was successfully selected for the “China Science and Technology Journal Excellence Action Plan” project, which has markedly improved its international influence and industry popularity. CHM obtained the first impact factor of 3.8 in Journal Citation Reports (JCR) in 2023.