Effect of targeted therapy for cystic fibrosis on course of pediatric chronic rhinosinusitis: first russian experience

Abstract

Cystic fibrosis is the most common hereditary disease characterized by multiple organ damage to the exocrine glands, one of the manifestations of which is chronic rhinosinusitis (CRS), often polyposis-purulent. A part of patients with this disease require multiple surgical interventions on the paranasal sinuses. With the arrival of targeted therapy, which intracellularly corrects the structure and function of the mutant protein and is directed primarily at treating manifestations of the lungs and pancreas, a positive effect on the course of CRS was also noted. The review of stages of development of this direction of treatment of cystic fibrosis is provided in the article, and also one of the Russia’s first similar clinical observations is given.