Clinical, Histological, and Molecular Perspective on Regenerating Nonvital Immature Teeth

IF 0.9 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Contemporary Clinical Dentistry Pub Date : 2023-01-01 DOI:10.4103/ccd.ccd_44_23

García-Guerrero Claudia, Mora-Pinza Tania, Quijano-Guauque Sara, Leal-Fernández Carolina, Baldión-Elorza Paula

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引用次数: 0

Abstract

Abstract Background: Disinfection and dentin conditioning promote a favorable scenario for regenerative endodontic treatment. Clinical reports have confirmed periapical normality with high variability in disinfection protocols; nevertheless, the nature of neoformed tissue varied between them. Thus, this study aimed to present the impact of disinfection protocols on the clinical, histological, and molecular outcomes of regenerative endodontics procedures in permanent teeth with incomplete root formation. Materials and Methods: Eighteen teeth with incomplete root formation which required endodontic regenerative treatment were treated with different disinfection and conditioning agents and followed under clinical control. One case was evaluated under histological and immunohistochemical analyses. Results: Clinical outcomes revealed periapical repair in 17/18 cases. Histological and immunohistochemical analyses confirmed the neoformation of the dentinal matrix and its mineralization. Conclusions: Chemical conditioning could impact the outcome of regenerative endodontic procedures. The histological and immunohistochemical analysis showed the nature of the newly formed tissue that correlates with the clinical outcome.

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非重要未成熟牙齿再生的临床、组织学和分子研究

背景:消毒和牙本质调理促进了再生根管治疗的良好前景。临床报告证实根尖周围正常，但消毒方案差异很大;然而，新生组织的性质在它们之间有所不同。因此，本研究旨在介绍消毒方案对牙根形成不完全的恒牙再生牙髓治疗的临床、组织学和分子结果的影响。材料与方法:用不同的消毒调理剂治疗18颗需要根管再生治疗的不完全根形成牙，并进行临床对照。1例进行组织学和免疫组织化学分析。结果:17/18例患者根尖周修复。组织学和免疫组织化学分析证实了牙本质基质的新生和矿化。结论:化学调理会影响再生根管治疗的效果。组织学和免疫组织化学分析显示新形成组织的性质与临床结果相关。

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来源期刊

Contemporary Clinical Dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

23 weeks

期刊介绍： The journal Contemporary Clinical Dentistry (CCD) (Print ISSN: 0976-237X, E-ISSN:0976- 2361) is peer-reviewed journal published on behalf of Maharishi Markandeshwar University and issues are published quarterly in the last week of March, June, September and December. The Journal publishes Original research papers, clinical studies, case series strictly of clinical interest. Manuscripts are invited from all specialties of Dentistry i.e. Conservative dentistry and Endodontics, Dentofacial orthopedics and Orthodontics, Oral medicine and Radiology, Oral pathology, Oral surgery, Orodental diseases, Pediatric Dentistry, Periodontics, Clinical aspects of Public Health dentistry and Prosthodontics. Review articles are not accepted. Review, if published, will only be by invitation from eminent scholars and academicians of National and International repute in the field of Medical/Dental education.