Developments for collagen hydrolysates as a multifunctional antioxidant in biomedical domains

Journal of Leather Science and Engineering Pub Date : 2023-09-26 DOI:10.1186/s42825-023-00131-9

Guiya Deng, Ke Huang, Xianchao Jiang, Kun Wang, Zihao Song, Yuchen Su, Chengming Li, Shuai Zhang, Shiqi Wang, Yaqin Huang

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Abstract

Antioxidant collagen hydrolysates refers to the peptides mixture with antioxidant properties identified from hydrolyzed collagen. Due to its specific structural, biological and physicochemical properties, collagen hydrolysates have been explored as a multifunctional antioxidant in the biomedical field. In this review, we summarize recent advances in antioxidant collagen hydrolysates development. Initially, the preparation process of antioxidant collagen hydrolysates is introduced, including the production and separation methods. Then the effects and the mechanisms of amino acid composition and collagen peptide structure on the antioxidant activity of collagen hydrolysates are reviewed. Finally, the applications of antioxidant collagen hydrolysates in biomedical domains are summarized, with critical discussions about the advantages, current limitations and challenges to be resolved in the future.

Graphical abstract

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胶原蛋白水解物作为多功能抗氧化剂在生物医学领域的研究进展

抗氧化胶原蛋白水解物是指从水解胶原蛋白中鉴定出的具有抗氧化特性的多肽混合物。胶原蛋白水解物由于其特殊的结构、生物学和理化性质，在生物医学领域已被开发为一种多功能抗氧化剂。本文综述了近年来抗氧化胶原蛋白水解物的研究进展。首先介绍了抗氧化胶原水解物的制备工艺，包括生产和分离方法。综述了氨基酸组成和胶原肽结构对胶原水解产物抗氧化活性的影响及其机理。最后，总结了抗氧化胶原蛋白水解物在生物医学领域的应用，并对其优势、局限性和未来需要解决的挑战进行了重点讨论。图形抽象

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来源期刊

Journal of Leather Science and Engineering 工程技术-材料科学：综合

CiteScore

12.80

自引率

0.00%

发文量