The influence of stereotaxic lesions of claustrum on motor movements and behaviour in rats.

Somatosensory & motor research Pub Date : 2024-12-01 Epub Date: 2023-11-16 DOI:10.1080/08990220.2023.2280563
Ahmet Eren Seçen, Didem Tuba Akçalı, Ergin Dileköz, Emin Çağıl, Denizhan Divanlıoğlu, Özgür Öcal, Hayrunnisa Bolay Belen
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Abstract

Background: This study aimed to expand our existing information on changes in the regulation of motor movement and behaviour by investigating the effects of unilateral and bilateral lesions on the claustrum (CL).

Material and methods: 36 Wistar Albino adult male rats were randomly divided into six groups. An electrical lesion was created with a constant current source in the unilateral and bilateral anterior clastrum using a stereotaxic frame in rats. The lesioned groups and the control group underwent an automatic behaviour recording device such as mobilisation, freezing, eating, drinking behaviour, grooming, turning, etc. behaviour was recorded and analysed. Simultaneously, ultrasonic sounds in rats were examined with ultrasonic sound recording program. Anxiety was then reassessed with the elevated plus maze test. Data were compared with the control group. Rats were eventually sacrificed and the brain tissue was post-fixed. Histochemical examination was done and lesions' existence was confirmed.

Results: In this study, lesions of ventral of CL can cause increase in spontaneous behaviours such as freezing and rearing. And, it has been shown to cause a statistically significant change. In addition to the behavioural changes, right CL lesions have caused a significant increase in drinking behaviour associated with increased anxiety. All operated groups showed a significant decrease in clockwise and counterclockwise rotation movements.

Conclusion: Experimental results show that CL lesions influence spontaneous behaviour which indicate the need for new studies to understand the role of CL in anxiety-depression.

屏状体立体定向损伤对大鼠运动和行为的影响。
背景:本研究旨在通过调查单侧和双侧损伤对屏状体(CL)的影响,扩大我们关于运动和行为调节变化的现有信息。材料与方法:Wistar Albino成年雄性大鼠36只,随机分为6组。用恒流源在大鼠单侧和双侧前屏上用立体定向框架制造电损伤。病变组和对照组分别采用自动行为记录仪对其活动、冻结、进食、饮水、梳理、翻身等行为进行记录分析。同时用超声录音程序检测大鼠的超声声音。然后用升高加迷宫测试重新评估焦虑。数据与对照组进行比较。大鼠最终被处死,脑组织被后固定。行组织化学检查,证实病变存在。结果:本研究中,CL腹侧病变可引起冷冻、饲养等自发行为增加。而且,它已经被证明会导致统计上显著的变化。除了行为上的改变,右脑CL损伤还会导致饮酒行为的显著增加,并伴随焦虑的增加。所有手术组的顺时针和逆时针旋转动作均明显减少。结论:实验结果表明,CL病变影响自发行为,需要新的研究来了解CL在焦虑-抑郁中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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