Renal Manifestations in Juvenile Idiopathic Arthritis (JIA) And The Use Of Monoclonal Antibodies For Its Treatment: A Systematic Review

Abstract

Juvenile idiopathic arthritis (JIA) is a group of chronicchildhood arthropathies in which various joints areaffected. Along with the joints being involved, long-standing arthritis can lead to other systemicinvolvements. Eyes, kidneys, and skin are someexamples. It is no surprise that we come across manypatients suffering from renal complications due to long-standing JIA. This systematic review aimed to focus onthe renal involvement seen in JIA and the use ofmonoclonal antibodies in its treatment. A systematicreview was performed using the PRISMA (PreferredReporting Items for Systematic Reviews and Meta-Analyses) guidelines and researching studies ondatabases like PubMed, PubMed Central, and GoogleScholar on June 26, 2022. Assessment tools likeCochrane, SANRA, and JBI Tool were used for qualityassessment and the selection of articles. Followed bythe quality assessment, seven studies were included inthe final selection. These were two randomized controltrials, four case reports, and one literature review. Inconclusion, many cases involving renal complicationsalong with JIA were seen, and Tocilizumab has provedto be efficacious in improving renal complications inJIA. This review encourages further study and researchinto the topic to understand the effects on JIA and theuse of monoclonal antibodies as therapy