High Proteasome Activity in Plasma of Patients with Hematologic Malignancy (Case of 145 Moroccan patients)

Abstract

Introduction: Present both in the cytoplasm and nucleus of all eukaryotic cells, the 20S proteasome can be detected in peripheral blood (serum or plasma) (Stoebner and al, 2005). The proteasome, proteolytic heart of “ubiquitin-proteasome pathway” has a very broad substrate spectrum, most play a role in: the cell cycle, DNA repair, apoptosis (p53 and Caspase) angiogenesis (VEGF), inflammation (NF-kB, IL6 ....) immune response (antigen presentation) (Adams, 2002).