[Increased proteolytic activity of cathepsin D in the skin of rats after administration of various anti-inflammatory drugs].

IF 0.5 Q4 DERMATOLOGY

Przeglad dermatologiczny Pub Date : 1990-09-01

J A Pałka, Z Galewska, K Wróbel

引用次数: 0

Abstract

Cathepsin D activity and type I and III collagens content in the skin of rats treated with some antiinflammatory drugs (acetylsalicylic acid, phenylbutazone, indomethacin, colchicine and prednisone) were evaluated. It was found that investigated drugs evoke increased activity of cathepsin D and decreased collagen content (mainly type I) in this tissue. The correlation between type I collagen content and proteolytic activity was noticed.

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[给药后大鼠皮肤组织蛋白酶D的蛋白水解活性增加]。

观察抗炎药(乙酰水杨酸、苯丁酮、吲哚美辛、秋水仙碱、强的松)对大鼠皮肤组织蛋白酶D活性及ⅰ、ⅲ型胶原含量的影响。研究发现，所研究的药物引起组织蛋白酶D活性增加，胶原含量(主要是I型)降低。注意到I型胶原含量与蛋白水解活性之间的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Przeglad dermatologiczny DERMATOLOGY-

CiteScore

0.80

自引率

14.30%

发文量

审稿时长

12 weeks

期刊介绍： Przegląd Dermatologiczny (ang. Dermatological Review) is a bimonthly magazine of the Polish Dermatological Association. It publishes original (clinical and experimental) papers, review papers, care reports, reports from congresses, reviews of books, announcements, letters to the editor and special papers (requested by the editors), concerning selected dermatological and interdisciplinary issues. Papers sent to the editor are reviewed.