The effect of the Mexidol on the dynamics of changes in hematological parameters in the indurative form of acute pancreatitis in dogs

Abstract

This article presents the results of the use of the Mexidol as a part of complex therapy for the relief of the indurative form of acute pancreatitis in dogs. The study was conducted to prove the validity of the use of synthetic antioxidants to alleviate the course of the disease, as well as to reduce the likelihood of complications after the resumption of the normal functioning of the pancreas. For this, studies were conducted on two groups of dogs with acute indurative pancreatitis. Group 1 was treated with classical therapy, and group 2, in addition to standard treatment, received Mexidol at a dose of 10 mg / kg. Analysis of hematological parameters of both groups of animals indicates a higher efficiency of treatment in group 2. In it, the absolute number of leukocytes in the blood after treatment decreased by 44%, while in the first group by 18%, the level of superoxide dismutase  in the blood became higher relative to the second group by 16%, the amount of serum elastase-1 (pancreatic elastase) was within the reference values, having decreased by 51%, in the first group by 17% (P<0.05). In connection with these data, there is a reason to include this preparation in the classical regimen for the treatment of acute indurative pancreatitis.