The Therapeutic Potential of DNA Aptamer for Dialysis-Related Amyloidosis

Abstract

β2m is a precursor protein of the dialysis-related amyloidosis (DRA) and β2m lacking the N-terminal six residues of the mature protein (ΔN6β2m) is a one of amyloidogenic variant of β2m. In the previous study, we had showed an unfolding in the C-terminal of ΔN6β2m using the specific monoclonal antibody for ΔN6β2m. We had also reported firstly an aptamer specific for ΔN6β2m. ΔN6β2m-aptamers specifically and tightly bound to ΔN6β2m and inhibited fibril formation. These results suggest the potential of ΔN6β2m-aptamers as reagents for therapeutic tools to prevent amyloid deposits in dialysis patients.