An Effect Of Methanol Extract Sunkist Orange Peel (Citrus Sinensis (L.) Osbeck) On Blood Sugar And Cholesterol Levels Wistar Rats (Rattus Norvegicus) Induced By Aloxan

Yolanda Eliza Putri Lubis, Reghita Claudia Malau, Rahmi Arianti, Maya Sari Mutia
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引用次数: 1

Abstract

Insulin resistance is a condition with damage to target organs that generally respond to the activity of the hormone insulin. About 10% of the population in big cities in Indonesia suffer from insulin resistance. At the cellular level, insulin resistance can result from damage to the pre-receptor, receptor, or post-receptor. The most common cause of insulin resistance is post-receptor damage, namely disruption and damage to insulin signaling pathways. To find out that the methanol extract of Sunkist orange peel can reduce blood sugar levels in Wistar rats. This research uses the experimental laboratory method in vivo with the chosen research design form, namely True Experimental Pre Test and Post Test Control. The Kruskal Wallis test showed that the Sunkist Orange Peel Methanol Extract resulted in a significant decrease in blood sugar levels of Wistar rats with a p-value <0.05, and also the Anova test showed that the Sunkist Orange Peel Methanol Extract resulted in a decrease in blood sugar levels of Wistar rats, which is significant with p-value <0.05. All doses tested affect lowering blood sugar levels, namely, 300 mg/kg BW, 450 mg/kg BW, and 600 mg/kg BW.
甲醇提取物对新奇士桔皮的影响Aloxan对褐家鼠(Rattus Norvegicus)血糖和胆固醇水平的影响
胰岛素抵抗是一种目标器官受损的情况,通常对激素胰岛素的活性有反应。在印度尼西亚的大城市中,约有10%的人口患有胰岛素抵抗。在细胞水平上,胰岛素抵抗可由前受体、受体或后受体的损伤引起。胰岛素抵抗最常见的原因是受体后损伤,即胰岛素信号通路的破坏和损伤。研究新奇士橘皮甲醇提取物对Wistar大鼠血糖的降低作用。本研究在体内采用实验实验室的方法,选择了真实实验前测和后测控制的研究设计形式。Kruskal Wallis检验显示,新奇士橘皮甲醇提取物对Wistar大鼠血糖水平有显著降低作用,p值<0.05;Anova检验显示,新奇士橘皮甲醇提取物对Wistar大鼠血糖水平有显著降低作用,p值<0.05。测试的所有剂量均能降低血糖水平,即300 mg/kg体重、450 mg/kg体重和600 mg/kg体重。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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