Transmembrane Carbon Nanotubes for Intracellular Stimulation

Shoichi Kanno, Zugui Peng, K. Shimba, Y. Miyamoto, T. Yagi
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引用次数: 1

Abstract

Carbon nanotubes (CNTs) are hollow cylindrical carbon materials with unique physical, mechanical, and electrical properties. Furthermore, CNTs cut to about 10 nm can spontaneously insert into cell membranes and artificial lipid membranes. Consequently, CNTs are attracting attention for their potential use as protective membranes for sensors, drug delivery systems, nano-dipolar electrodes, and other applications when combined with lipid membranes. CNTs with hydrophobic surfaces can interact with the hydrophobic membrane core to induce membrane deformation. Although changes in membrane morphology are one cause of cytotoxicity, the effects of cut CNTs on membrane morphology are not well understood. In this study, we exposed CNTs to artificial cell membrane vesicles (giant unilamellar vesicles), which are used as a cell model, and evaluated the changes in membrane morphology for each CNT concentration by fluorescence microscopy.
细胞内刺激的跨膜碳纳米管
碳纳米管是一种中空的圆柱形碳材料,具有独特的物理、机械和电学性能。此外,切至10 nm左右的碳纳米管可以自发地插入细胞膜和人工脂质膜。因此,当CNTs与脂质膜结合时,其作为传感器保护膜、药物传递系统、纳米偶极电极和其他应用的潜在用途引起了人们的关注。具有疏水表面的碳纳米管可以与疏水膜芯相互作用,引起膜变形。虽然膜形态的改变是细胞毒性的一个原因,但切割CNTs对膜形态的影响尚不清楚。在本研究中,我们将CNTs暴露于人工细胞膜囊泡(巨大的单层囊泡)中,作为细胞模型,并通过荧光显微镜评估了每种CNT浓度下膜形态的变化。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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