Gabor domain optical coherence microscopy

Abstract

Optical Coherence Microscopy (OCM) is an emerging technology capable of depth sectioning of biological tissue at the micrometer scale. In this paper, we propose a developing technology we call Gabor Domain Optical Coherence Microscopy (GD-OCM), whose innovation is two folds: (1) A high lateral resolution optical design of a dynamic-focusing optical probe with no moving parts, which provides an invariant resolution of currently 3 μm across a 2mm full-field of view and 2mm imaging depth by design; (2) An acquisition scheme (using the probe) that is capable of performing automatic data fusion to render an in-focus high resolution image throughout the depth of sample at in vivo speeds.