Optimization Techniques Applications in Biochemical Engineering and Controlled Drug Delivery

Abstract

Before starting semi-pilot/pilot production plants for biochemical metabolites production, it is essential to optimize the fermentation media. This chapter discusses the classical and advanced techniques of media optimization. The statistical approaches save experimental time for developing processing and improving quality. Recent years have seen the growth of integrated approaches of microbial cultures. Optimization techniques such as response surface methodology, artificial neural network, genetic algorithms, differential evolution, ant colony optimization, etc. have received attention recently because of their major applications in various fields. Controlled release formulations have so many versatile applications in the field of pharmaceutical drugs that they have become important tools to apply the modern concept of therapeutic treatment. Process optimization of such formulations, mathematical modelling can play an important role. This chapter discusses various methodologies for optimization of formulation conditions for drug delivery.