Antiobesity Properties of Star Fruits Extract and its Combination with Toddalia Aculeata Leaves Extract

Proceedings of the 1st International Conference on Education, Humanities, Health and Agriculture, ICEHHA 2021, 3-4 June 2021, Ruteng, Flores, Indonesia Pub Date : 1900-01-01 DOI:10.4108/eai.3-6-2021.2310747

I. Sundari, D. Indarto, P. Dirgahayu

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Abstract

. The existing pharmacological therapy of obesity often causes side effects. Therefore, this study aimed to explore active compounds derived from star fruits and Toddallia acuelata leaves extracts for development of obesity therapy. From phytochemical screening test, it was found that star fruits extract (SFE) contained alkaloids, phenolics, and flavonoids while T. acuelata leaves extract (TLE) contained alkaloids, phenolics, saponins, and steroids. Based on the in-silico study confirmed with a chemical analysis using the Liquid Chromatography-Mass Spectrometry (LC-MS) technique, SFE contained Epicathecine Gallate (tannin derivative). Furthermore, the highest antioxidant activity was detected in pure TLE (58.5%) followed by combination of 25: 75% SFE and TLE (46.81%). In conclusion, TLE and combination of 25:75% star fruits and T. acuelata extracts become a potential obesity therapy. Further research is required for the investigation of pharmacological properties of those extracts.

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杨桃提取物的抗肥胖特性及其与龙葵叶提取物的配伍

。现有的肥胖药物治疗往往会产生副作用。因此，本研究旨在探索杨桃和牛牙叶提取物的活性成分，以开发肥胖治疗药物。通过植物化学筛选，发现杨桃提取物(SFE)中含有生物碱、酚类物质和黄酮类物质，而刺叶提取物(TLE)中含有生物碱、酚类物质、皂苷和甾类物质。通过液相色谱-质谱(LC-MS)技术的化学分析证实，SFE中含有没食子表酸酯(单宁衍生物)。其中，以纯TLE的抗氧化活性最高(58.5%)，其次为25.75% SFE和TLE的组合(46.81%)。综上所述，TLE和25:75%杨桃与牛蒡提取物联合使用是一种潜在的肥胖治疗方法。这些提取物的药理性质有待进一步研究。

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Proceedings of the 1st International Conference on Education, Humanities, Health and Agriculture, ICEHHA 2021, 3-4 June 2021, Ruteng, Flores, Indonesia

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