[Topical administration of cyclosporin in psoriasis vulgaris].

Zeitschrift fur Hautkrankheiten Pub Date : 1990-06-01
T Bunse, H J Schulze, G Mahrle
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Abstract

Two groups of patients with chronic plaque psoriasis were topically treated either with 10% cyclosporin in a jelly base or with 5% cyclosporin in an ointment base under occlusion. We found that cyclosporin penetrates into the lower epidermis and the dermis, when it is applied under occlusion. Obviously, the target cells are neutrophil granulocytes, since they decrease in number under cyclosporin, whereas the other inflammatory cells as well as the epidermal proliferation remain unchanged. In contrast to systemic application of cyclosporin, we did not observe any clinical differences between plaques treated with cyclosporin and those treated with placebo.

局部应用环孢素治疗寻常型银屑病。
两组慢性斑块型银屑病患者在闭塞状态下局部使用10%环孢素果冻基或5%环孢素软膏基进行治疗。我们发现环孢素在闭塞状态下可渗透到下表皮和真皮。显然,靶细胞是中性粒细胞,因为在环孢素作用下,它们的数量减少,而其他炎症细胞和表皮增殖保持不变。与系统应用环孢素相比,我们没有观察到环孢素治疗斑块与安慰剂治疗斑块之间的任何临床差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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