Expression of HLA class I antigens in human tumors and their involvement in tumor growth.

C Salerno, T Crepaldi, P Savoia, P Richiardi
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引用次数: 8

Abstract

A decreased expression of major histocompatibility complex (MHC) class I antigens is a common feature of many experimental and human tumors and can often be correlated with malignancy grade. In fact, reduction of class I antigens is associated in most tumors with an enhanced ability to elude immune surveillance. Loss of HLA-A,B,C antigens ranges from a decrease in the percentage of A,B,C-positive cells to selective loss of particular antigens and total loss of class I molecule expression. In man, this has been documented in melanomas, carcinomas, lymphomas, neuroblastoma and acute leukemias. The reduction in membrane antigens is generally associated with a parallel fall in immunoprecipitable intracellular proteins and the corresponding mRNAs in the absence of structural changes in the coding genes. The literature concerning the above mentioned topics is reviewed and discussed.

HLA I类抗原在人类肿瘤中的表达及其在肿瘤生长中的作用。
主要组织相容性复合体(MHC) I类抗原的表达降低是许多实验和人类肿瘤的共同特征,并且通常与恶性程度相关。事实上,在大多数肿瘤中,I类抗原的减少与逃避免疫监视的能力增强有关。HLA-A、B、C抗原的缺失范围从a、B、C阳性细胞百分比的减少到特定抗原的选择性缺失和I类分子表达的完全缺失。在人类中,这在黑色素瘤、癌、淋巴瘤、神经母细胞瘤和急性白血病中都有记载。在没有编码基因结构变化的情况下,膜抗原的减少通常与免疫可沉淀的细胞内蛋白和相应mrna的平行下降有关。本文对有关上述主题的文献进行了回顾和讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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