Identifying Transcription Factor Binding Sites in Promoters of Human Genes

Abstract

Transcription factor binding sites play an important role in the regulation of gene expression. This study develops a different computational approach to discover putative TFBSs in 17407 human promoters. 89 8-mer sequences are discovered from this research, including 12 new putative TFBSs. All these 12 putative TFBSs show peaks at the location upstream from TSS. 30 out of 89 sequences were also discovered by FitzGerald et al. (FitzGerald et al. 2004), 63 out of 89 sequences match the motifs discovered by Xie et al. (Xie et al. 2005) and 20 out of 89 sequences match the TRANSFAC motifs built from TRANSFAC database by Xie et al. The only predicted TFBS by FitzGerald is verified by our research