The effects of duloxetine augmentation on clozapine in the treatment of negative symptoms in treatment resistant schizophrenia

Ritvij M Satodiya
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Abstract

The negative symptoms of schizophrenia have always been a challenge in treatment. The intensity and chronicity of these symptoms has direct impact on the life quality and treatment response. Current psychopharmacological agents have not offered a satisfactory result in addressing the negative symptoms of schizophrenia. The clinicians struggle with the approaches that can be utilized to target the negative symptoms of schizophrenia as no well-defined evidence exist. We present a case of treatment resistant schizophrenia with negative symptoms that responded well with augmentation of Duloxetine to Clozapine treatment.
加重度洛西汀对氯氮平治疗难治性精神分裂症阴性症状的影响
精神分裂症的阴性症状一直是治疗中的一个挑战。这些症状的严重程度和慢性程度直接影响患者的生活质量和治疗效果。目前的精神药理学药物在解决精神分裂症的阴性症状方面没有提供令人满意的结果。由于没有明确的证据存在,临床医生与可用于针对精神分裂症阴性症状的方法斗争。我们提出一个病例的治疗抵抗精神分裂症与阴性症状,反应良好,增加度洛西汀氯氮平治疗。
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