ANALGESIC AND ANTI-INFLAMMATORY EFFECTS OF HYDROALCOHOLIC EXTRACT OF SALVIA MULTICAULIS ON MALE RATS

Abstract

Aims: One of the most basic methods for coping with diseases and pain relief had been the use of medicinal plants. The aim of this study was to the determination of analgesic and anti-inflammatory effects of Salvia multicaulis hydroalcoholic extract. Materials & Methods: In this experimental study, 42 male Wistar rats were divided in 6 groups (n=7); the control (receive nothing), the sham (receive solvent intraperitoneally) and 4 groups that received plant extract at the doses of 50, 100, 200 and 400mg/kg intraperitoneally. Tail flick and formalin test were used for evaluation of thermal and chemical pain, also for assessment the degree of inflammation, rat paw edema volume was acquired by plethysmometric test. Data were analyzed in SPSS 16 software by ANOVA with repeated measuring and T student tests. Findings: The intraperitoneally injection of extract in all doses decreased the chemical pain induced by formalin (p<0.05). Hydroalcoholic extract of plant at doses 200 and 400mg/kg caused hyperalgesia in compared with control group (p<0.01). All concentrations of hydroalcoholic extract of plant decreased the inflammation (p<0.01). Conclusion: Intraperitoneally administration of hydroalcoholic extract of Salvia multicaulis has analgesic effects.