{"title":"[Chemoreflex modification of the myocardial contractility of rabbits].","authors":"H Opitz, K Scheufler","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The effects of arterial hypoxia on the minute ventilation (AMV), the heart interval (HI), the contractility index (KI = (P/P) max., the left ventricular systolic pressure (LVSP), and the pressure-increase-time RP were tested before and after infusion of a selective stimulator of the arterial chemoreceptors (0.5 mg/kg Almitrine-Bismesylate). The arterial blood-pH and the paO2 were increased by Almitrine whereas the paCO2 was decreased significantly. The AMV is elevated, the heart interval and the RP-interval are reduced, KI and LVSP increase after Almitrine. The hypoxia-effects after changing the paO2 from 19 to 9 kPa are an increase of AMV, KI, LVSP and a shortening of HI and RP. These effects were intensified by Almitrine. The hypoxia effects were not changed by vagotomy. A correlation between the increase of the respiration and the appertaining cardiac effects was not discovered.</p>","PeriodicalId":77647,"journal":{"name":"Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur experimentelle Chirurgie, Transplantation, und kunstliche Organe : Organ der Sektion Experimentelle Chirurgie der Gesellschaft fur Chirurgie der DDR","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The effects of arterial hypoxia on the minute ventilation (AMV), the heart interval (HI), the contractility index (KI = (P/P) max., the left ventricular systolic pressure (LVSP), and the pressure-increase-time RP were tested before and after infusion of a selective stimulator of the arterial chemoreceptors (0.5 mg/kg Almitrine-Bismesylate). The arterial blood-pH and the paO2 were increased by Almitrine whereas the paCO2 was decreased significantly. The AMV is elevated, the heart interval and the RP-interval are reduced, KI and LVSP increase after Almitrine. The hypoxia-effects after changing the paO2 from 19 to 9 kPa are an increase of AMV, KI, LVSP and a shortening of HI and RP. These effects were intensified by Almitrine. The hypoxia effects were not changed by vagotomy. A correlation between the increase of the respiration and the appertaining cardiac effects was not discovered.
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