Tissue and Drug Specificity of Drug Sensitivities in Different Cancer Cell Lines

Abstract

Cancer cell lines are widely used in cancer research and medical science, but the usefulness and efficacy of using cancer cell lines remains controversial. In this study, I used the data from CCLE (Cancer Cell Line Encyclopedia) to investigate the tissue and drug specificity of drug sensitivities in different cancer cell lines. I fitted a sigmoid relationship between the dose amount and the median drug response, then used the fitted parameters to represent the drug sensitivity of each cell line. By using PCA (Principal Component Analysis), KNN (K-nearest neighbors) and multinomial logistic regression, there is no evidence supporting that there is any cancer cell lines clustering.