LUNG ASPERGILLUS NIGER INFECTION AFTER SARS-COV2

Abstract

"A 64-year-old never-smoker man, with professional exposure, presented to Marius Nasta Pneumophtisiology Institute for fatigability to effort, in the context of severe SARS-COV2 infection one month previously. His medical history includes pulmonary tuberculosis (55 years ago) and newly diagnosed type II diabetes (261 mg/dL glycemia). Clinical examination revealed no modification, except kyphoscoliosis, pale teguments and mucosa, and diminished vesicular breath sounds on the right side. Blood pressure was 130/70 mmHg, heart rate 96 beats per minute, and oxygen saturation level was 92%. Electrocardiogram revealed sinus rhythm and right bundle branch block. Spirometry showed FEV1 = 3.57 L (115.5%) and FVC = 4.36 L (110.1%). Pulmonary volumes and capacities were normal, but alveolar-capillary diffusion was slowly reduced, with decreased transfer coefficient. Biochemical analysis of the blood revealed the following abnormalities: microcytic hypochromic anemia (hemoglobin 10.7 g/dL, hematocrit 33.8 %, MCV 64.9 fL, MCH 20.5 pg, MCHC 31.7 g/dL), thrombocytosis (375 x 10 3 / µL), hypoproteinemia (total proteins 5.9 g/dL) and increased TGP/ALT (94 U/L). VSH level was normal."