Muscle metabolism in older adults

Abstract

Sarcopenia is a generalized progressive skeletal muscle disease that is associated with an increased risk of disability and death due to falls and fractures. The article details current information about the age-related features of metabolism and muscle tissue remodeling, which lead to the development of sarcopenia and its further progression. The possibilities of correcting sarcopenia are presented: the mechanism of action of experimental drugs acting on muscle tissue (myostatin, bimagrumab, landogrosumab) and non-drug methods of correcting sarcopenia (nutrition, physical activity) that have proven the effectiveness of non-drug methods for correcting sarcopenia (nutrition, physical activity) are analyzed, and the possible effects of taking vitamin D preparations for patients with sarcopenia are described.