A Monolithic Lab-on-a-Chip for Real Time Liquid Spectroscopy

Abstract

We present a monolithic mid-infrared lab-on-a-chip for sensitive and selective real-time liquid spectroscopy. Beyond state-of-the-art operation of our fingertip-sized devices is demonstrated by in-situ reaction-monitoring of thermally-induced protein-conformational changes and by dynamical residual-water analysis in solvents.