A microelectronic circuit in CADENCE analogous to michaelis complex of β-lactamase protein

Abstract

In the present paper a microelectronic circuit in Cadence functionally analogous to Michaelis complex of β-lactamase protein is investigated. The hydrogen bonding networks are described by electrical circuits. Block elements are made for each residue from protein hydrogen bonding networks, which are functionally analogous to residues and describe the proton transport. The block-elements are coded and described in Cadence with polynomials and DC and transient analyses were carried out. The simulation results are compared to electronic circuit and elements.