Quadratic-backtracking algorithm for string reconstruction from substring compositions

Abstract

Motivated by the problem of deducing the structure of proteins using mass-spectrometry, we study the reconstruction of a string from the multiset of its substring compositions. We specialize the backtracking algorithm used for the more general turnpike problem for string reconstruction. Employing well known results about transience of random walks in ≥ 3 dimensions, we show that the algorithm reconstructs random strings over alphabet size ≥ 4 with high probability in near-optimal quadratic time.