The mechanism and research progress of circRNA-microRNA in regulating osteogenesis

Abstract

Jaw defect and alveolar bone absorption are the main oral problems in today’s society. In recent years, studies have found that changes in the expression of different miRNAs can affect the osteogenic effects of stem cells. With the in-depth study of its upstream circRNA, it has been found that circRNA can pass it acts as a molecular sponge of microRNA to indirectly regulate osteogenesis, so how to select a suitable and stable circRNA has become the focus of attention. In this review, we have collected and sorted out circRNA and its functions, the application and process of mirRNA to regulate osteogenic differentiation, and a list of several miRNAs closely related to osteogenesis and relatively mature researches, aiming to find suitable circRNA upstream Therefore, it is expected to be used in the clinical repair of oral bone defects.