Brain Metastasis in HER2-Positive Breast Cancer: Case Report and Review of Literature

Abstract

Introduction: Breast cancer (BC) is one of the most common cancers in women in developed countries. Approximately 15 to 20% of patients with BC have tumors with elevated levels of Human Epidermal Growth Factor Receptor 2 (HER2), which are associated with an aggressive clinical phenotype and poor prognosis. Brain metastases (BM) appears in more than 15% in the HER2-positive breast cancer population, which cause serious decrease in survival.