Characterization of the ADP-ribosylation of actin by Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin.

Journal de physiologie Pub Date : 1990-01-01

K Aktories, U Geipel, M Wille, I Just

引用次数: 0

Abstract

Clostridium botulinum C2 toxin and Clostridium perfringens iota toxin belong to a novel family of actin ADP-ribosylating toxins. ADP-ribosylation of actin inhibits actin polymerization and G-actin-associated ATPase activity. The ADP-form of actin is ADP-ribosylated at a higher rate than actin with bound ATP. ADP-ribosylation of actin is reversible, a reaction, which is accompanied by reconstitution of actin ATPase activity.

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肉毒杆菌C2毒素和产气荚膜梭菌毒素对肌动蛋白adp核糖基化的影响。

肉毒梭菌C2毒素和产气荚膜梭菌毒素属于一种新的肌动蛋白adp核糖基化毒素家族。肌动蛋白的adp核糖基化抑制肌动蛋白聚合和g -肌动蛋白相关的atp酶活性。与结合ATP的肌动蛋白相比，adp形式的肌动蛋白以更高的速率进行adp核糖化。肌动蛋白的adp核糖基化是可逆的，这是一个伴随着肌动蛋白atp酶活性重建的反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal de physiologie

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