Electrochemical Oxidation Assisted with the 1,3-Dipolar Cycloaddition for the Synthesis of the New Substituted Triazole

Abstract

The electrochemical reaction of 4-ethynylaniline ( 4-EA ) in the present of sodium azide in buffered solutions with the various pHs (buffer solution /acetonitrile (80/20 v/v)) was investigated for the first time. Our electrochemical data assert that the product of oxidation of 4-ethynylaniline enter in the chemical reaction with azide ion. In continues, after the 1,3 dipolar cycloaddition, electrochemical oxidation, dimerization and third step electrochemical oxidation a triazole ring was produced as a desired product in a simple undivided cell and using carbon anode. The critical aim in this study was applying a non-catalytic procedure for the synthesis of triazole ring in the room temperature that successfully achieved.